P68 a Study to Investigate the Clinical Use and Outcomes of Ezpap Positive Pressure Device

P70 Figure 1 Correlation between consecutive number of hours in which patients scored #2 SIRS criteria and percentage change from baseline concentration of CRP. CRP was measured in plasma samples using ELISA. Data analysed using Spearman’s rank correlation. r1⁄4correlation, SIRS1⁄4systemic inflammatory response syndrome. P71 RELATIONSHIP BETWEEN QUADRICEPS RECTUS FEMORIS CROSS-SECTIONAL AREA AND HEALTH RELATED QUALITY OF LIFE IN PATIENTS FOLLOWING CRITICAL ILLNESS doi:10.1136/thoraxjnl-2011-201054c.71 B Connolly, J Moxham, N Hart. Department of Asthma, Allergy & Respiratory Science, Division of Asthma, Allergy and Lung Biology, King’s College London, London, UK; Guy’s & St Thomas’ NHS Foundation Trust and King’s College London, National Institute of Health Research Comprehensive Biomedical Research Centre, London, UK Introduction Quadriceps rectus femoris cross-sectional area (RFCSA) is considered a useful marker of quadriceps strength with a 20% reduction in RFCSA observed in critically ill patients at 10 days after admission to the intensive care unit (ICU). This has clinical importance in patients following the acute critical illness episode as it is postulated that quadriceps muscle wasting reduces quadriceps muscle strength and as a consequence impairs physical activity and health-related quality of life (HRQL). We therefore hypothesised that RFCSA would have a direct relationship with HRQL. Method Patients were assessedwithin 48 h of discharge from the ICU to the ward as part of an ongoing multicentre randomised controlled trial. RFCSAwas determined using real-time B-mode ultrasonography using an 8MHz 5.6 cm linear transducer (PLM805, Toshiba Medical Systems Ltd, Crawley, UK) at a distance three-fifths from anterior superior iliac spine to the superior patellar border. HRQL was measured using the self-reported hospital anxiety and depression (HAD) scale and the short form-36 v2 (SF-36) questionnaire. Higher scores indicate better HRQL from the SF-36 questionnaire and lower scores indicate better HRQL from the HAD scale. Results 17 post critical care patients were recruited. Mean age was 60.7614.9 years with 64.7% (n1⁄411) female. Mean body mass index (BMI) was 26.066.4 kg/m and fat-free mass index (FFMI) was 16.863.9 kg/m. The correlations between RFCSA and HRQL are shown in Abstract P71 table 1. Abstract P71 Table 1 Relationships between RFCSA and HRQLP71 Table 1 Relationships between RFCSA and HRQL